Building Capacity for a Global Genome Editing Observatory: Institutional Design

Academic and institutional capacity: a global issue.

Building Institutional Capacity in Digital Preservation

The Chronicles in Preservation project, being led by the Educopia Institute, is undertaking research to evaluate the degree to which several of the current digital preservation standards in use today (e.g., OAIS, TRAC, PREMIS, METS, etc.) can be applied to the diverse and at-risk content genre of digital newspapers. Institutions need guidance on incremental, skilled approaches and lightweight t...

Building institutional capacity for diversity and inclusion in academic medicine.

Today, most agree that the health care system in the United States is in need of reform and that existing health disparities have huge implications for both that system and society as a whole. As a result, academic medicine has come to play a central role in addressing health disparities in a pluralistic society. Today, diversity is no longer a projection; it is a reality. Yet, most diversity e...

Capacity Building in Global Mental Health Research

Research-generated information about mental disorders is crucial in order to establish the health needs in a given setting, to propose culturally apt and cost-effective individual and collective interventions, to investigate their implementation, and to explore the obstacles that prevent recommended strategies from being implemented. Yet the capacity to undertake such research in low- and middl...

Expanding CRISPR/Cas9 Genome Editing Capacity in Zebrafish Using SaCas9

The type II CRISPR/Cas9 system has been used widely for genome editing in zebrafish. However, the requirement for the 5'-NGG-3' protospacer-adjacent motif (PAM) of Cas9 from Streptococcus pyogenes (SpCas9) limits its targeting sequences. Here, we report that a Cas9 ortholog from Staphylococcus aureus (SaCas9), and its KKH variant, successfully induced targeted mutagenesis with high frequency in...